which booster is better moderna or pfizer

U.K. study finds mRNA COVID-19 vaccines provide biggest booster impact, Ontario needs to better track vaccines tied to breakthrough cases, expert says, Pfizer-BioNTech launch trial of Omicron-targeted COVID-19 vaccine, Moderna says booster shot of its COVID-19 vaccine should protect against Omicron, Nova Scotia opens up COVID-19 vaccine booster doses to 18+. Vaccination process Both Pfizer and Moderna have launched studies of Omicron-specific boosters. When it comes to 18 to 29-year-olds, Grindrod said Pfizer is generally the recommended vaccine. For months, public health officials have urged people to get any COVID-19 vaccine available to them. More info. Barbra A. Dickerman, Hanna Gerlovin, Arin L. Madenci, Michael J. Figueroa Muiz, Jessica K. Wise, Nimish Adhikari, Brian R. Ferolito, Katherine E. Kurgansky, David R. Gagnon, Kelly Cho, Juan P. Casas & Miguel A. Hernn, Comparative effectiveness of third doses of mRNA-based COVID-19 vaccines in US veterans. Modernas vaccine relies on a lipid nanoparticle that can deliver the larger dose. The Centers for Disease Control and Prevention (CDC) now recommends that all adults aged 18 and older get a COVID-19 booster shot. But truly, how much does this difference matter in the real world?, Its not appropriate for people who took Pfizer to be freaking out that they got an inferior vaccine.. All rights reserved. Powered and implemented by Interactive Data Managed Solutions. Their results are expected to confirm that you'll probably get the same side effects with the same levels of severity from either shot.. While the main portion of the study was conducted when Alpha was the dominant strain, the researchers found that Moderna also had better efficacy during an additional research phase when Delta was the main circulating strain. doi:10.1056/NEJMoa2115463. Vaccine manufacturers would typically have enough time to test a range of doses before choosing one and they have done such testing for their trials of the coronavirus vaccine in children. Your questions answered, Half of people offered Moderna vaccine refuse it if they want Pfizer, Ontario pharmacists say. We need to keep studying this and to do more research, but I think its plausible.. But the numbers are small. People who got the Moderna vaccine for their original shots and Moderna again for their booster appear to have gotten the best immune response, followed by those who got Pfizer boosted by Moderna and then Moderna boosted by Pfizer although the increase in immune response with the mRNA vaccines was probably too small to really make a difference in protection in most groups. 2023 Fortune Media IP Limited. People ages 5 and older who had all recommended doses of a COVID-19 vaccine can get the Pfizer-BioNTech COVID-19 updated, or bivalent, booster. Modernas vaccine relies on a lipid nanoparticle that can deliver the larger dose. She said it may be because the dosage is different between thevaccines. Is there an association between COVID-19 vaccination and changes in ovarian reserve? The vaccines differ in their dosing and in the time between the first and second doses. Data from Europe on the AstraZeneca vaccine, which is similar to J&J, show that an mRNA booster is substantially more potent than giving a second dose of the same viral vector vaccine. Children ages 12 to 17 who were vaccinated with either Modernas or Pfizer-BioNTechs shots as their primary series can get boosted with Pfizer-BioNTechs new Omicron booster. News-Medical, viewed 28 June 2023, https://www.news-medical.net/news/20230103/Study-compares-effectiveness-of-Pfizer-vs-Moderna-booster-COVID-vaccines-after-third-dose.aspx. DOI. Also, researchers measured antibody levels two and four weeks after the booster. WebHowever, the eligibility criteria shared by the Department suggest that individuals aged 18 and over can choose either of the four bivalents: Pfizer BA.1, Moderna BA.1, Pfizer BA.4/5, and Moderna BA.4/5. Key Takeaways. Most importantly, these studies should account for the time windows of the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. During nine weeks of follow-up amid Omicron predominance, the estimated risk of documented SARS-CoV-2 infection was higher with a third dose of the BNT162b2 vaccine vs. mRNA-1273. Within family chat we have people who have a reaction to Pfizer but not Moderna and also the other way around. Australians can access Moderna's BA.4/5 bivalent vaccine in April, Bivalent boosters targeting Omicron's original variant and BA.1 variant are available to residents. Protection from both waned over time, particularly after the arrival of the Delta variant, but the Pfizer-BioNTech vaccines values fell lower. Victorian Chief Health Officer Professor Brett Sutton urged state residents to get their 2023 booster dose as most had their last COVID vaccine six months ago. Doctors recommend getting vaccinated and boosted, when eligible. There are some caveats to this study that make it a little hard to know how to interpret the data. Viral clearance: A potential predictor of COVID-19 treatment efficacy, https://doi.org/10.1038/s41564-022-01272-z, https://www.nature.com/articles/s41564-022-01272-z, Effectiveness of up-to-date COVID-19 vaccination in preventing SARS-CoV-2 infection among nursing home residents: study reveals 31.2% protection. "I just got my Moderna two days ago and it was an interesting experience. Doctors recommend getting vaccinated and boosted, when eligible. The latest such study, published on Wednesday in The New England Journal of Medicine, evaluated the real-world effectiveness of the vaccines at preventing symptomatic illness in about 5,000 health care workers in 25 states. Adults ages 18 years and older who received one or two J&J COVID-19 vaccine doses are recommended to receive one bivalent mRNA dose (Moderna or Pfizer-BioNTech) at least two months after completion of the previous dose. Study compares effectiveness of Pfizer vs. Moderna booster COVID vaccines after third dose. While any vaccine is better than none, new research has found that there is a slight difference in how effective the Moderna and Pfizer-BioNTech vaccines are. Information in this article was accurate at the time of original publication. The results don't come as a complete surprise. For those who received a Moderna booster, antibody levels increased 11-fold. Heres what the original efficacy data on each vaccine was: However, data has shown that vaccine efficacy wanes over time. Until there's some future vaccine designed specifically to target the highly transmissible Omicron variant, adults in Canada are encouraged to get their booster shot as soon as possible which means either Pfizer or Moderna. Among those who had Pfizer for their first two shots, a third Pfizer dose saw antibody levels rise more than eightfold. Adults ages 18 years and older who received one or two J&J COVID-19 vaccine doses are recommended to receive one bivalent mRNA dose (Moderna or Pfizer-BioNTech) at least two months after completion of the previous dose. "The provisional registration for the bivalent vaccines only supports their use as a booster dose at this time," it said. ", Last fall, the Ontario government offered a similar recommendation due to a "mild risk" of the rare heart condition myocarditis "out of an abundance of caution.". Thank you, {{form.email}}, for signing up. The most significant finding suggested that people who initially got the J&J vaccine seem to have gotten the best response if they got Pfizer or Moderna as their booster. Key Takeaways. The data from the NIH study will be reviewed by advisers to the Food and Drug Administration later this week as part of a meeting to consider requests from both Moderna and J&J to authorize booster doses of their vaccines. The researchers also say that their study wasn't designed to compare varying responses among the different booster regimens and that the data set isn't large enough to reach conclusions about one versus the other. Dr. Iris Gorfinkel, a Toronto-based family doctor and vaccine researcher, emphasized that when it comes to reducing hospitalizations, both are "extremely effective. We would have all seen that as great result and been happy with it, he said. But the discrepancy is small and the real-world consequences uncertain, because both vaccines are still highly effective at preventing severe illness and hospitalization, she and others cautioned. Dr. Bruce Turner, the C.E.O. For months, public health officials have urged people to get any COVID-19 vaccine available But vaccine makers are confused by murky regulatory guidance. Both the Moderna and Pfizer mRNA COVID-19 vaccines are highly effective. reported symptomatic SARS-CoV-2 infection. "Over time, that higher dose might be what is driving the difference in protective efficacy," John Moore, a microbiology and immunology professor at Weill Cornell Medicine, told The Atlantic last year. (accessed June 28, 2023). Key Takeaways. Results from those studies can be skewed by any number of factors, including the location, the age of the population vaccinated, when they were immunized and the timing between the doses, Dr. Dean said. To get either one, you'll need to be at least two months removed from completing a primary vaccine series or receiving any other Covid shot. Pfizer went with 30 micrograms, Moderna with 100. By clicking "Allow All" you agree to the storing of cookies on your device to enhance site navigation, Should kids under 12 get the COVID vaccine? (2023, January 04). FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. WebHowever, the eligibility criteria shared by the Department suggest that individuals aged 18 and over can choose either of the four bivalents: Pfizer BA.1, Moderna BA.1, Pfizer BA.4/5, and Moderna BA.4/5. Associate Professor Stuart Turville from the Kirby Institute at the University of New South Wales said all available vaccines boost protective antibodies against all circulating viruses. News-Medical. A greater antibody response following an mRNA booster compared to a viral vector booster was not surprising. However, its important to note that the dose of the Moderna booster given in the study was twice as high as what will be given in the real world. An earlier version of this article referred incorrectly to the nanoparticle used in Moderna's vaccine. The Pfizer-BioNTech booster is a full dose. More data on booster shots is still needed, she said. FDA panel recommends updating Covid booster shots for fall. ", For its part, J&J said the "study demonstrated that a booster of the Johnson & Johnson COVID-19 vaccine increases immune response regardless of a person's primary vaccination and confirm previously published data on the strong increase of immune response when the Johnson & Johnson COVID-19 vaccine is administered as a booster shot.". For each veteran in the primary analysis, the team started follow-up on the day of the third vaccination (baseline). "There's actually more mRNA in the half-dose Moderna than the full dose Pfizer. However, the eligibility criteria shared by the Department suggest that individuals aged 18 and over can choose either of the four bivalents: Pfizer BA.1, Moderna BA.1, Pfizer BA.4/5, and Moderna BA.4/5. The Pfizer-BioNTech and Moderna vaccines rely on the same mRNA platform, and in the initial clinical trials, they had remarkably similar efficacy against symptomatic infection: 95 percent for Pfizer-BioNTech and 94 percent for Moderna. The study, which was sponsored by the National Institutes of Health, involved 458 volunteers. The researchers then measured antibody levels in all of those people two weeks and four weeks after the boost. "If you get a Moderna or Pfizer first, it really doesn't matter what mRNA vaccine you get next," Dr. Monica Gandhi, an infectious disease specialist at the University of California, San Francisco, told NPR. The antibody levels of people in those groups went up 10 to 20 times higher than in those people who got another J&J shot. A report from the U.S. Centers for Disease Control and Prevention found that vaccine effectiveness against Omicron hospitalization fell to just 57 per cent in people who were more than six months out from a second shot, but grew to 90 per cent with a booster. Lyke says that at the end of the day, the Pfizer and Moderna vaccines are very similar, and both offer excellent protection. As booster shots roll out across the country, Moderna may be a better choice for many over the age of 30 because of its slightly longerprotection against infection, said Grindrod, thepharmacy vaccine lead for the Waterloo region. Here's What You Need To Know. The veteran population of the second emulated trial received the third dose of any of the two mRNA COVID-19 vaccines between 1 January and 1 March 2022, the period of only Omicron predominance. Retrieved on June 28, 2023 from https://www.news-medical.net/news/20230103/Study-compares-effectiveness-of-Pfizer-vs-Moderna-booster-COVID-vaccines-after-third-dose.aspx. SBS is committed to providing all COVID-19 updates to Australias multicultural and multilingual communities. And that antibody increase is probably big enough to make a difference in how much better the protection will be, scientists say. Comparing Pfizer with Moderna, you see another dose difference: Each shot of Pfizer contains 30 micrograms of mRNA, while each one of Moderna contains 100. While some Canadians who have received their booster shots have later tested positive for COVID-19, medical experts agree that the science behind booster jabs is sound. This was in part why they were described as more or less equivalent. Scientists who were initially skeptical of the reported differences between the Moderna and Pfizer-BioNTech vaccines have slowly become convinced that the disparity is small but real. Vaccination process New data show the Moderna vaccine is slightly more effective than the Pfizer vaccine. Centers for Disease Control and Prevention. Scientists had initially hoped that the vaccines would have an efficacy of 50 or 60 percent. A study by the National Institutes of Health this week suggests people who got the J&J vaccine as their initial vaccination against the coronavirus may get their best protection from choosing an mRNA vaccine as the booster. It is available to eligible Australians through primary care channels from 6 March. Clinical decisions relating to types of vaccines are matters for individuals and their vaccine providers, Adverse reactions following Pfizer bivalent BA.4/5 as a second booster dose included pain at the injection site (68.5%), fatigue (56.4%), headache (41.4%), muscle pain (25.8%), chills (16.9%), joint pain (13.4%), fever (7.3%), injection site swelling (5.4%), injection site redness (4.8%), and lymphadenopathy (0.3%), The Moderna and Pfizer Bivalent Original/Omicron BA.1 vaccines are available for those eligible and who want to receive their booster now. https://www.news-medical.net/news/20230103/Study-compares-effectiveness-of-Pfizer-vs-Moderna-booster-COVID-vaccines-after-third-dose.aspx. Pfizer and Moderna's bivalent booster both use mRNA technology combining the original COVID-19 vaccine along with the reformulation targeting the BA.4 and BA.5 versions of the omicron variant. The Moderna booster shot is a half dose. Pfizer went with 30 micrograms, Moderna with 100. The median age of this veteran population was 70 years, 96% were males, and 24% were Blacks. Americans have two options for a new omicron-specific Covid booster shot: Pfizer or Moderna. New research is showing how well boosters are holding up in the Omicron wave still protecting against infection, symptoms and hospitalization. FILE - Pfizer, left, and Moderna bivalent COVID-19 vaccines are readied for use at a clinic, Nov. 17, 2022, in Richmond, Va. Next COVID vaccine booster shot should target new variant not original virus, FDA panel says. For months, public health officials have urged people to get any COVID-19 vaccine available You may want The study found that the Pfizer-BioNTech vaccine had an effectiveness of 88.8 percent, compared with Modernas 96.3 percent. This result was unsurprising to Moore, who says, There are no inherent safety issues that go beyond the individual [vaccine] components. "Moderna does seem to have a more durable protection, which is going to protect you for potentially a bit longer against those breakthrough infections," Grindrod said. SBS acknowledges the Traditional Custodians of Country and their connections and continuous care for the skies, lands and waterways throughout Australia. "Study compares effectiveness of Pfizer vs. Moderna booster COVID vaccines after third dose". Based on those data, the company asked the F.D.A. The Pfizer-BioNTech booster is a full dose. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. Is COVID-19 severity of infection a new risk factor for chronic pain? analyse site usage and support us in providing free open access scientific content. The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical. They had a higher proportion of men and White people. News-Medical. Box 500 Station A Toronto, ON Canada, M5W 1E6. Something similar was seen in the U.K. when people who got the AstraZeneca vaccine which is similar to the J&J shot got boosters. By comparison, only people who are at a greater risk for severe illnessthose who are over 65, have a preexisting condition, or work in a high-risk settingshould get a Pfizer or Moderna booster. But by now, the observational studies have delivered results from a number of locations Qatar, the Mayo Clinic in Minnesota, several other states in the United States and in health care workers, hospitalized veterans or the general population. Posted in: Medical Research News | Disease/Infection News | Pharmaceutical News, Tags: Coronavirus, Coronavirus Disease COVID-19, covid-19, Efficacy, immunity, Intensive Care, Microbiology, Omicron, Pandemic, Respiratory, Ribonucleic Acid, SARS, SARS-CoV-2, Severe Acute Respiratory, Severe Acute Respiratory Syndrome, Syndrome, Technology, Vaccine, Veterans Affairs. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice| Do Not Sell/Share My Personal Information| Ad Choices During the 16-week follow-up spanning Delta and Omicron prevalence, the researchers documented 2,994 SARS-CoV-2 infections, of which 200 were symptomatic COVID-19 cases, 194 sought hospitalization, 52 needed ICU admission, and 22 culminated in death. However, mRNA-1273 recipients had a lower risk of COVID-19-related adverse events over 16 weeks of follow-up than the BNT162b2vaccine recipients, particularly for reported SARS-CoV-2 infections. Our baseline assumption is that the mRNA vaccines are functioning similarly, but then you start to see a separation, said Natalie Dean, a biostatistician at Emory University in Atlanta. The most significant finding suggested that people who initially got the J&J vaccine seem to have gotten the best response if they got Pfizer or Moderna as their booster. She has experience in pre-clinical research as part of her research project in The Department of Toxicology at the prestigious Central Drug Research Institute (CDRI), Lucknow, India. Mathur, Neha. Whether or not you will be offered a COVID-19 booster shot is based on each province or territory's eligibility criteria and rollout plan. Ultimately, both vaccines are still holding steady against severe illness and hospitalization, especially in people under 65, Dr. Moore said. Reynold Panettieri,MD, vice chancellor for translational medicine and science at Rutgers University, told Verywell that people should absolutely not think that one mRNA vaccine is better than the other. 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In Pfizer and Moderna's clinical trials for earlier versions of bivalent boosters that targeted omicron's BA.1 and BA.2 subvariants, participants reported the same common side effects for each shot: In both clinical trials, most participants reported their side effects as very mild or even non-existent. People ages 5 and older who had all recommended doses of a COVID-19 vaccine can get the Pfizer-BioNTech COVID-19 updated, or bivalent, booster. In an email to NPR, Nathaniel Landau, a microbiologist at the New York University Grossman School of Medicine, said the findings show that getting a J&J booster after the initial one-shot immunization is "not as good" as receiving one of the mRNA vaccines as a booster. The two shots have very similar formulations and different dosage amounts. Moderna Vaccine May Lead to Fewer Breakthrough Infections Compared to Pfizer, White House: Most Americans Will Need Booster Shot 8 Months After Vaccination, What You Need to Know About the Updated COVID-19 Boosters. The Pfizer-BioNTech booster is a full dose. But Moderna asked the FDA for a 50-microgram booster because of concerns about side effects. Moderna's shot is a bigger dose than Pfizer's. Moderna's new booster, like its previous vaccine, is a slightly larger dose (50 micrograms) than Pfizer's (30 micrograms). Pfizer's booster is cleared for anyone 12 and older, while Moderna's booster is for people 18 and older. In addition, the researchers tested full doses of all the vaccines not the half-dose that Moderna is seeking authorization for in its booster. Panettieri said that, as of now, the greatest risk to people with COVID-19 is being unvaccinated, and the second greatest risk is not getting the booster.. The number of hospitalizations and infections per 1,000 people are extraordinarily low with both vaccines, he said. The extra week may give immune cells more time to proliferate before the second dose, said Dr. Paul Burton, Modernas chief medical officer. WATCH | Medical experts explain whythe science behind boosters is sound: But there is some research showing that for older populations or for those who have weaker immune systems, Moderna may offer slightly more protection against breakthrough infections, Grindrod said. Experts weigh in | CBC Radio Loaded. People ages 5 and older who had all recommended doses of a COVID-19 vaccine can get the Pfizer-BioNTech COVID-19 updated, or bivalent, booster. For those who received a Moderna booster, antibody levels increased 11-fold. Its not a huge difference, but at least its consistent.. Accordingly, the estimated risk ratio was 1.57, presented as events per 10,000 individuals. Some countries, including the US, are considering BA.4/5 vaccines as primary doses. Probably not. Dr. Bruce Turner, the C.E.O. Federal health officials say both shots will serve as a desperately needed layer of protection for the coming months, as the weather turns colder and immunity from previous vaccines wanes. Health officials say the new shots will enhance your immunity at a crucial time, regardless of whether you get Pfizer or Moderna. Both the Moderna and Pfizer mRNA COVID-19 vaccines are highly effective. with these terms and conditions. Verywell Health's content is for informational and educational purposes only. Associate Professor Jane Frawley from the University of Technology Sydney said eligible residents may prefer BA.4/5 vaccines over the original boosters. The vaccines have never been directly compared in a carefully designed study, so the data indicating that effects vary are based mostly on observations. But if someone has a weakened immune system or has more risk factors, Grindrod leans towards recommending Moderna for a booster shot. Doctors and public health officials have said that people should get whichever booster shot is readily available to them. "One thing that is clear in a number of studies is that you need to be beyond two doses of vaccine to provide levels of neutralising antibodies to cover the Omicron lineages presently in circulation," Prof Tuville said. "I worry about over interpretation of our data," says Dr. John Beigel of the the National Institute of Allergy and Infectious Diseases. The Moderna booster shot is a half dose. (file) Credit: Lisa Maree Williams/Getty Images, This is what the WHO revealed about people who have hybrid immunity from COVID-19, Sydney WorldPride 2023: How Sydney's LGBTQI+ community and gay bars bounced back from pandemic. Prof Tuville said it is difficult to predict the next variant and how it would differ from the current ones. Moderna's booster is a half dose of the original vaccine, with 50 micrograms of mRNA in it. In one of their previous work covering 439,684 US veterans, researchers found that both mRNA-1273 and BNT162b2 lowered the risk of SARS-CoV-2 infection and severe disease outcomes during SARS-CoV-2 Alpha variant prevalence.

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