frontiers in immunology impact factor 2023

n is the sample size of male and female astronauts that participated in the study. * Correspondence: GT and OL participated in the concept and design. The Frontiers in Immunology Impact Factor has steadily increased over the years, reflecting immunology researchs growing importance and impact. In addition to the 2-year Impact Factor, the 3-year Impact Factor, 4-year Impact Factor, 5-year Impact Factor, Real-Time Impact Factor can also provide further insights into the impact of Frontiers in Immunology. Visit for all Journals Impact factor List. doi: 10.1152/japplphysiol.00761.2018, 8. Received: 24 Nov 2022; Accepted: 27 Jun 2023. 14:1171103. doi: 10.3389/fimmu.2023.1171103. WebSec. Of interest, the biological term regulation of body fluid represented in the short list of genes in C2 displayed a pattern of upregulation when reaching space. These results confirm the decrease-then-increase pattern of gene C1 identified in the temporal gene cluster analysis (Figure2). Comparing transcriptomes at PF and IF2 time points, we identified 112 downregulated genes and eight upregulated genes (Figure3). The impact Factor is calculated annually by dividing the total number of citations received by articles published in the previous two years by the total number of papers published in the same period. Frontiers' philosophy is that all research is for the benefit of humankind. Performance & security by Cloudflare. 3D microenvironment attenuates simulated microgravity-mediated changes in T cell transcriptome. Artificial intelligence (AI) and machine learning: AI and machine learning are being used to analyze large datasets of immune system data, such as genetic profiles and resistant cell populations. (2008) 63(710):697705. Ranks #3 on Impact Factor 1.9 times the average in open-access journals in Immunology. Sample principal component scores were calculated from the variance stabilizing transformation (VST) of normalized read counts for the 59,901 genes. The other cluster included terms describing the regulation of immune system processes such as leukocyte activation and lymphoid organ development (Figure3). Our study also identified additional expression changes at phase transitions in genes unrelated to specific immune functions, such as cell population regulation. Brain Behav Immun [Internet] (2014) 39:2332. 9.8. The JCR provides quantitative tools for ranking, evaluating, categorizing, and comparing journals that are indexed on the two indexes mentioned above. The size of each dot is proportional to the enrichment factor (size scale) and color represents the FDR adjusted p-values, where darker points have lower values (color scale). A decrease in circulating red and white blood cells restores blood cell concentrations to maintain homeostasis, consistent with the downregulation of genes involved in cellular proliferation (10). Stress related shift toward inflammaging in cosmonauts after long-duration space flight. Details of the inventory of libraries included with randomly assigned astronaut identifiers and time points that passed quality metrics are provided in Table1. Frontiers in Immunology continues to rank among the worlds top immunology journals in terms of influence and quality, as shown by our analysis of the This transcriptomic response is consistent with the head ward fluid shift and subsequent hemoconcentration of blood cells occurring when entering space (38). The Associate Editor initially checks that the article meets basic quality standards and has no obvious objective errors. The impact factor should be used while being vigilant to the many circumstances that affect citation rates, for example, the average number of citations in an average article. This website is using a security service to protect itself from online attacks. With an Impact Factor of 6.429, Frontiers in Immunology is the 5th most-cited Immunology journal in the world. This abbreviation ('Front. Significant GO terms from the temporal gene clusters with >1.5 enrichment were displayed onto a dot plot. The chart shows the ratio of a journal's documents signed by researchers from more than one country; that is including more than one country address. The impact factor is pretty beneficial in explaining the importance of total citation frequencies. RNA sequencing removed ribosomal RNA and was biased toward protein-coding genes; changes in other RNA biotypes would have been missed. Gene z-scores for the 15,410 genes were then plotted across time as violin plots (Supplementary Figure4). Gene candidate profiles identified from both temporal and time-point differential expression analyses were bio-typed according to the functionality of RNA transcribed from these genes. The horizontal red line represents where the static tree cut was made to separate and define the two clusters of differentially expressed genes across time. The protocol for blood collection, centrifugation, and storage was the same for all blood samples including those collected onboard of the ISS. Bio-type annotation was done using the biomaRt package in R environment (18, 19), which utilized the Vega archive gene classifications (https://vega.archive.ensembl.org/info/about/gene_and_transcript_types.html). Front Physiol (2019) 10(FEB):113. Demontis GC, Germani MM, Caiani EG, Barravecchia I, Passino C, Angeloni D. Human pathophysiological adaptations to the space environment. This thus makes JCR redundant. Shannon P, Andrew Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, et al. The impact score (IS) 2022 of Frontiers in Immunology is 6.92, which is computed in 2023 as per its definition. The first analysis of the leukocyte transcriptomes provided an overview of the relative transcriptional changes occurring at 10 time points across the three phases of a space mission: PF, IF, and R. Astronauts leukocyte transcriptomes showed opposite directions of gene expression changes upon reaching the space environment compared to the return on Earth. To our knowledge, this represents a novel finding. In 2020, we were the 3rd most-cited publisher, increasing average citations from 3.9 in 2019 to 4.8 in 2020 for every article published with us. Acta astronaut. Submission. It is published by Frontiers Media S.A.. Cluster headers are the GO term with the highest enrichment factor within that cluster. Peripheral blood cells are an ideal candidate to probe systemic effects due to their contact with multiple- organ systems through blood circulation. That is why Frontiers provides online free and open access to all of its research publications. Funder mandates such as those by the Wellcome Trust (UK), National Institutes of Health (USA) and the Australian Research Council (Australia) are fully compatible with publishing in Frontiers. Immunol.. Check Out IF Ranking Prediction Trend Key Factor Analysis. 1. Of the 112 genes downregulated early IF, 100 (89.3%) of those same genes were upregulated immediately upon return to Earth. The work can be freely shared and adapted provided that appropriate credit is given and any changes specified. If the same downward trend persists, HOME PRIVACY POLICY FRONTIERSIN.ORG, 2021 Frontiers Media S.A. All Rights Reserved. By Mischa Dijkstra, Frontiers science writer Scientists have shown that the expression of (mostly protein-coding) genes in white blood cells changes rapidly when doi: 10.1016/S0959-440X(00)00167-6, 46. ISI was acquired by Thomson Scientific & Healthcare in 1992 and was renamed Thomson ISI. Genome Biol (2014) 15(12):121. This means that the same genes responded to both transitions to and from microgravity despite the occurrence of different physiological changes. This subset of genes was identified from the Venn diagram overlap between the differentially expressed gene profiles for PF vs. IF2 and IF4 vs. R1 (Figure4). Received: 31 December 2022; Accepted: 27 March 2023; Published: 11 April 2023. shows a falling trend. Principal component scores were calculated using the prcomp() function in R for all 72 samples. Early studies have also reported that, within 1 week in microgravity, red blood cell mass decreases ~10% (9). Garrett-Bakelman FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, et al. This study bears a number of limitations. New Research: Impaired function of dendritic cells within the tumor microenvironment: Dendritic cells (DCs), a class of professional antigen-presenting cells, In other words, we can say that the higher the impact factor, the higher the rank of a journal. According to SCImago Journal Rank (SJR), this journal is ranked 2.022. Durinck S, Moreau Y, Kasprzyk A, Davis S, De Moor B, Brazma A, et al. doi: 10.1093/bioinformatics/bti355, 21. New technique published in Frontiers in Robotics and AI allows artists to do just that. Many of our journals rank among the most influential in their fields, including the most cited in neurosciences, immunology, microbiology, plant science, and psychology. B = the total number of citations published during 2020 and 2021. Copyright 2023 Stratis, Trudel, Rocheleau, Pelchat and Laneuville. Table1 Sample inventory: libraries that passed quality metrics and used for sequencing. Immunology is a rapidly evolving field of study that focuses on understanding how the immune system works and how it can be manipulated to prevent or treat diseases. SJR is a measure of scientific influence of journals that accounts for both the number of citations received by a journal and the importance or prestige of the journals where such citations come from Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. The 6 head- down tilt bedrest model replicates the microgravity component of spaceflight with many of the physiological changes happening in space including fluid shift, muscle atrophy, bone loss, and hemolysis (4144). One sample was not collected leaving 139 blood samples for RNA-sequencing. It is usually used as a way to measure the relative importance of a journal within its field; journals that have higher impact factor values are considered to be more important or higher status. It is also the 1st most cited open-access journal in Immunology. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). This may bear physiological significance given the ~20% increases in hemolysis in the same astronauts 1 year after returning from space (10, 39). It considers the number of citations received by a journal and the importance of the journals from where these citations come. Trudel G, Shafer J, Laneuville O, Ramsay T. Characterizing the effect of exposure to microgravity on anemia: more space is worse. Therefore, this sample was treated as a technical outlier and excluded from further analyses leaving 71 samples for analysis in silico. For instance, blood samples were collected within a window of days rather than on a specific day that introduced variability. Marc D. Beyer, German Center for Neurodegenerative Diseases, Helmholtz Association of German Research Centers (HZ), Bonn, 53127, North Rhine-Westphalia, Germany, View all Should it become clear that a particular reviewer has a conflict of interest or is unable to perform the peer-review timely and adequately, he or she shall be replaced with an alternative reviewer by the Associate Editor or the Chief Editor, who will be alerted and has full control to intervene into the peer-review at any time. Web Comparing Clinical and Imaging Features of Patients with MOG Antibody. AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL. Coverage history of this journal is as following: 2010-2022. B cell homeostasis is maintained during long-duration spaceflight. Asterisk (*) indicates non-coding genes. Only leading researchers acting as Associate Editors, who are not part of Frontiers staff, can make acceptance decisions based on reviews performed by external experts acting as Review Editors or reviewers. Table2 Summary of selective time-point differential expression results. You can email the site owner to let them know you were blocked. respective specialty section. impact score may fall in 2023 as well. Laity JH, Lee BM, Wright PE. Nat Methods (2016) 13(7):57780. (2 years)). The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1171103/full#supplementary-material. doi: 10.1152/japplphysiol.00935.2015, 43. In many research fields such as mathematics, a major part of the intellectual output is usually published in the form of books, which are not considered a part of the database; therefore, they have no impact factor. Z-scores represent the average normalized read counts for the 14 astronauts scaled across the 15,410 genes at each individual time-point. Whereas, the following upregulation of ZAPs when returning to Earth may be a response to suppress the replication of herpes viral particles. 8 Articles, This article is part of the Research Topic, You just subscribed to receive the final version of the article, Creative Commons Attribution License (CC BY). Transcriptome composition changed in opposite directions at transitions between ambulation and bedrest and between bedrest and re-ambulation in 20 healthy participants submitted to 60 days of bedrest (40). Our impact metrics reflect the power of research that is open to all. Those studies offered valuable insight into the molecular interactions occurring during spaceflight but suffer from small astronaut sample sizes and lack an integrated time-dependent analysis. Total RNA was suspended in 20 l of RNAse-free water, and quality was assessed using the Agilent BioAnalyzer 2100 (Model G2939B, Agilent, Santa Clara, CA, USA). It is the frequency with which an average article in a journal has been cited in a particular year or period. We measure and communicate a range of metrics, including Impact Factor, CiteScore, overall citation rate, aggregate views and downloads, and news and social media mentions. C1 genes had above average expression PF but had below average expression 1-year post-flight, and vice versa for C2. 662,863. The LFC values relative to PF were calculated for a subset of gene candidates identified from the differential expression analysis of selective time points. Frontiers in Immunology portrays how advances of scientific knowledge and technology may translate into novel approaches to diagnosis and treat immune disorders, both in animal and cellular models and in humans.

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